Adrian Thrasher is Professor of Paediatric Immunology and Honorary Consultant Paediatric Immunologist at Great Ormond Street Hospital for Children NHS Foundation Trust. He has a long standing research and clinical interest in development and application of gene therapy for patients with primary immunodeficiency, especially Wiskott-Aldrich Syndrome (WAS), disorders of innate immunity, and Autoimmune Lymphoproliferative Syndrome. His team at UCL GOSICH/GOSH are conducting trials of somatic gene therapy for various forms of PID including SCID-X1, CGD, ADA-SCID, and WAS and also research the pathophysiology of primary immunodeficiency syndromes, the actin cytoskeleton in haematopoietic cells, and thymus transplantation.