monday 10 March
12:00-12:45
Registration, Lunch & Posters
12:45-13:00
Presidential Welcome Address & Welcome of Organizer
​Frank Buchholz, Technical University Dresden & Zoltan Ivics, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig
13:00-14:25
Session 1: CRISPR Screens​
Chair: Boris Fehse, University of Hamburg
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13:00-13:20 Michael Boutros, Heidelberg University
INV01: Dissecting context-dependent genetic vulnerabilities
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13:20-13:40 John Fielden, ETH Zürich
INV02: Comprehensive Interrogation of Synthetic Lethality in the Human DNA Damage Response
13:40-13:55 Pratik Mallick, Technische Universität München
OR01: Establishment of a stable episomal replicon system for HBV to screen novel RNA-based antiviral gene therapies​
13:55-14:10 Sebastian Erkens, Witten/Herdecke University
OR02: A direct comparison of the Sleeping Beauty Transposon system and the CRISPR/Cas9 machinery for genetic engineering​
14:10-14:25 Martina Ruby, Cytiva
OR03: Using High-Throughput Genetic Screening to Improve Stable AAV Producer Cell Lines and to enhance viral vector production
14:25-14:45
Comfort Break
14:45-16:15
Session 2: Delivery
​Chair: Sandy Tretbar, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig
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14:45-15:05 Achim Aigner, University of Leipzig
INV03: Polymeric nanoparticles for RNA delivery: genome editing and beyond
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15:05-15:25 Ansgar Santel, Pantherna, Hennigsdorf
INV04: Beyond the Liver: Lipidnanoparticles (LNP) for Precise mRNA Delivery
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15:25-15:45 Hildegard Büning, Hannover Medical School
INV05 Capsid engineered AAV vectors as next generation in vivo delivery tools ​​
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15:45-16:00 Paul Scholz, Akribion Therapeutics
OR04 Programmable genome disruption enables selective elimination of cancer cells using a novel CRISPR-Cas nuclease​​
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16:00-16:15 Jonas Kath; Charité University Medicine
OR05 ‘One-pot’ PASTA - Advanced T cell Engineering through Precise Integration of Super-Large Exogenous DNA
16:15-16:45
Coffee Break
16:45-18:10
Session 3: Clinics
​Chair: Ulrike Köhl, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig​
16:45-17:05 Jürgen Foell, Universitätsklinikum Regensburg
INV06: ​CRISPR/Cas9: therapeutic application in sickle cell anemia (SCD) and transfusion-dependent ß-thalasemia
17:05-17:25 Axel Schambach, Hannover Medical School
INV07: Clinical translation of safer vectors and precision gene editing tools
17:25-17:40 Malte Ritter, University Hospital Tuebingen
OR06 Gene editing for pre-leukemia bone failure syndrome, severe congenital neutropenia, – current advances and critical considerations​
17:40-17:55 Tobias Bexte, Goethe University
OR07 CRISPR-edited allogeneic BCMA-CAR NK cells to overcome loss-of-target in multiple myeloma​
17:55-18:10 Ina Luksch, Technische Universität München
OR08 AAV-mediated gene therapy in a porcine model of Duchenne Muscular Dystrophy
18:30-20:00
Guided Tour of DHMD
20:00
Dinner at Pulverturm an der Frauenkirche
An der Frauenkirche 12,
01067 Dresden
TueSDAY 11 March
09:00-09:15
Registration & Welcome with coffee
09:15-09:50
Keynote
​Chair: Toni Cathomen, University of Freiburg
9:15-9:50 Kathleen Collins, Berkeley University
INV08: ​​Harnessing R2 retrotransposon machinery for site-specific safe-harbor transgene addition to the human genome​
09:50-11:25
Session 4: Genome editing technologies
​Chair: Zoltan Ivics, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig
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09:50-10:10 Toni Cathomen, University of Freiburg
INV09: Safer Genome Editing: Innovations in Off-Target Management
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10:10-10:30 Felix Lansing, Seamless Therapeutics, Dresden
INV10: ​Programmable recombinases to treat genetic diseases
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10:30-10:50 Zoltan Ivics, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig
INV11: ​Advances in Sleeping Beauty transposon engineering of therapeutic cells
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10:50-11:10 Marc Güell, Pompeu Fabra University, Barcelona
INV12: ​Levering bioprospecting and generative AI to create new gene writers​​
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11:10-11:25 Evangelia Anagnostou, University of Freiburg
OR09 An enhanced Single-Strand Break-Based Strategy for safer and more efficient Genome Editing
11:25-12:00
Coffee break & posters
12:00-13:30
Session 5: Ethics
​​Chair: Frank Buchholz, Technical University Dresden
Moderator: Nadia Primc, University of Heidelberg
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12:00-12:20 Karla Alex, University of Heidelberg
INV13: The ethics of human genome editing
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12:20-12:40 Klaus Tanner, University of Heidelberg
INV14: Ethics through bureaucracy. The limits of formal rationality
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12:40–13:30 Panel discussion
13:30
Lunch and Posters