Session 1: Optimizing the vector world and modeling systems – Part A

Chairs: Hildegard Büning, Hannover Medical School; Axel Schambach, Hannover Medical School

14:00-14:15

Hildegard Büning, Hannover Medical School; Axel Schambach, Hannover Medical School

Optimizing the vector world – current status in a nutshell

INV01 14:15-14:45

Els Verhoeyen, University of Nice, ENS Lyon ⓘ

Novel lentiviral pseudotypes for T and NK cell gene therapy and ‘nanoblades’ for efficient gene editing in hematopoietic gene therapy target cells.

INV02 14:45-15:15

Leszek Lisowski, University of Sydney

Canonical AAV gene therapy and clinical gene editing: capsid evolution and translational vectorology

INV03 15:15-15:45

Joel Rurik, University of Pennsylvania ⓘ

CAR T cells produced in vivo to treat cardiac injury

OR01 15:45-16:00

Rajendra Khanal, Hannover Medical School

mRNA-based therapies for liver diseases: HNF4A mRNA administration via lipid nanoparticles mitigates liver fibrosis in preclinical models

OR02 16:00-16:15

Zoltan Ivics, Paul Ehrlich Institute, Langen

Engineered Sleeping Beauty transposase redirects transposon integration away from genes